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Remit and terms of reference

Clinical studies group steering committee
The CSG is headed by the chair and a steering group who have responsibility for approving the submission of a clinical study application to the ARUK Clinical Studies Sub-committee.

The steering group is multidisciplinary with extensive experience in clinical trials, topic area, methodology and impact.

Given the training opportunities held within the CSG process, ARUK Fellows in metabolic bone disease and fracture will be matched to the steering group and/or TSG as appropriate.

Topic specific groups
These will be in four broad areas:
1. Osteoporosis and fragility fracture reduction
2. Musculoskeletal Trauma
3. Rare bone disorders
4. Vitamin D across the life course

There is an email list to provide two-way communication with CSG and the wider stakeholder groups.

The Arthritis Research UK Metabolic Bone Disease and Fracture CSG mission is to improve outcomes in patients with metabolic bone disease and fracture through research.

The CSG strategy is provide the academic infrastructure through a coordinated transparent collaboration approach to:
1. Define the most important questions
2. Support the development clinical studies to a highly competitive standard

This is delivered through three interlinking groups: the clinical studies group (CSG), the topic specific groups (TSG) and the constituency.

The remit of the CSG is to
1. Support the development of competitive study applications from feasibility, pilot to full study applications. This will be delivered through: impartial, confidential, expert evaluation and advice for investigators, matching the needs of the study with the appropriate skill mix within the UK and providing resources such as workshops.
2. Provide applications for clinical studies
3. Review Expression of Interest applications for clinical studies and from the TSGs.
4. Work in collaboration with other ARUK CSGs both through topic specific groups, workshops and funding applications
5. Facilitate network partnerships with other charities, funders and industry
6. Provide a point of contact for advice for other bodies regarding the research priorities within metabolic bone disease and fracture
7. Provide feedback on activity of CSG to all stakeholders

The remit of the TSG is to
1. To provide a forum to develop and update a portfolio of high priority clinical questions across within the TSG remit, through coordinating regular multi-stakeholder consultations and workshops.
2. Review Expression of interests for clinical studies within the TSG remit.
3. Identify areas within an application that require clarification in terms of population, intervention, comparator and/or outcomes
4. Provide impartial and expert consensus statements or process to develop consensus in terms of population, intervention, comparator and/or outcomes.
5. Provide high priority applications to the CSG for further development
6. Provide feedback on activity of the TSG to all stakeholders

The remit of the Constituency
1. To provide an email address to receive outputs from the CSG/TSG
2. Optional provision of balanced feedback for research applications

Frequency of formal meetings

CSG steering group:
1. Teleconference every 2 months
2. Three face to face/year

Topic specific groups:
1. Teleconference every quarter
2. One Face to face/ year

1. Email (quarterly update)

Membership will be for four years with the possibility of renewal.
This is a voluntary non-remunerated position with expenses for second class / economy travel and reasonable accommodation.

CSG Duties
1. Attend all least 80% of meetings and teleconferences of the CSG
2. Providing independent critiques for study applications received by CSG
3. Contribute the highest level of excellence within the CSG
4. Promote and develop the aims of the CSG

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