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Exploring the role of bacterial communities in psoriatic arthritis

Award Details

  • Principal Investigator
    Professor Anne Barton
  • Type of grant
    Special Strategic Award
  • Amount Awarded
  • Institute
    University of Manchester
  • Location
  • Status
  • Start Date
  • Grant reference number
  • Condition
    Psoriatic Arthritis

What are the aims of this research?

This research aims to test whether bacteria living on the skin or in the gut predispose to the risk of developing psoriatic arthritis or influence the response to treatment in patients with psoriatic arthritis. It also aims to investigate if these bacterial populations correlate with the genetic make-up and immune system of different subsets of people.

Why is this research important?

There is growing evidence that shows that the bacteria that live in and on the body contribute to disease and the success of therapies. Researchers will analyse the types of bacteria, genes and immune cells from, people with and without psoriasis or psoriatic arthritis, psoriatic arthritis patients before and after treatment and patients given different treatments, to investigate if the type of bacterial communities correlate with the genetic make-up of patients or the immune cells they carry. This will show how the genetic and environmental factors interact to predispose to psoriatic arthritis and influence treatment response.

How will the findings benefit patients?

Most patients have psoriasis before they develop psoriatic arthritis, meaning there is a window of opportunity to prevent them from getting arthritis. Understanding the risk factors from certain bacterial communities would lead the way for directed altering through diet, antibiotics and other lifestyle changes with the aim to easily prevent the onset of arthritis. Similarly, response to treatment may be impacted by the bacterial communities and understanding which bacteria affect response to particular treatments could allow better targeting of the right treatments to the right patients within the next five-ten years.

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