We're using cookies to give you the best experience on our site. Cookies are files stored in your browser and are used by most websites to help personalise your web experience.

By continuing to use our website without changing the settings, you're agreeing to our use of cookies.

Find out more

Is methotrexate and adalimumab causing frequent urination?

Q) I am 55 years old and have endured rheumatoid arthritis for 39 of them. For the past five years I have been taking methotrexate, 20 mg weekly, and adalimumab (Humira) 40 mg fortnightly, for which I am very grateful as they have increased my quality of life enormously. However, I suffer badly from a side-effect that both drugs can give and that is more frequent urination. I need to go at least once every hour, sometimes more, during the day and night. This ‘problem’ has a huge impact on my life and especially makes any kind of travel a nightmare. Do you regularly hear of this side effect or am I just unlucky?   
Ruth, via email (Summer 2014)

A) This is not something I hear about from my patients. I do see more frequent infections in my patients, including infections of the bladder and kidneys, and I remind my patients that is important to take any infection seriously when you are on these drugs. Our policy is to suggest temporary discontinuation of the drugs until the infection has gone.

However, it doesn’t sound like that in your case. There are other causes of polyuria (excessive amounts of urine) that could be investigated. (These would include forms of diabetes, including sugar diabetes). Perhaps the first thing to check is the total volume of urine you pass in 24 hours – if you do this make sure you also measure the total volume you drink in the same period and this will help your doctors if they wish to take this further.

This answer was provided by Dr Philip Helliwell for the Summer 2014 edition of our magazine, Arthritis Today, and was correct at the time of publication.

Send your questions for Dr Tom Margham to

Keep up to date with the latest from Arthritis TodaySign up today.


0800 5200 520

Our new helpline: Call us for free information, help and advice on your type of arthritis. Open Mon–Fri 9am–8pm.

All calls are recorded for training and quality purposes

Virtual Assistant

Our new Arthritis Virtual Assistant uses artificial intelligence to answer your arthritis related questions 24/7.

Ask a question

We're now

Versus Arthritis.

You're being taken through to our new website in order to finish your donation.

Thank you for your generosity.

For more information, go to
Arthritis Research UK fund research into the cause, treatment and cure of arthritis. You can support Arthritis Research UK by volunteering, donating or visiting our shops.