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Tips on methotrexate

New biological therapy is making a big difference to my condition

It might interest your readers to know I have recently been put on tocilizumab infusions as part of a methotrexate taper trial after methotrexate started to lose effectiveness. I felt the difference almost immediately (inside two weeks) and my first blood test showed C-reactive protein (CRP), a test to measure disease activity, and erythrocyte sedimentation rate (ESR), another diagnostic test that shows the level of inflammation, of 1 and 2 respectively. Now after a couple of infusions my disease activity score (DAS) is less than 1 and I'm in remission. Nothing I can say or give can do justice to the work of organisations like yours and companies like Roche that have made this possible.
Harry, via email (Spring 2014)

Side-effects of methotrexate

Having read the Questions and Answers section in Arthritis Today Summer 2009, I wonder if I may be able to suggest a potential solution to a question posed by Marilyn from Southampton regarding troublesome mouth ulcers. I have also experienced problems with recurrent mouth ulcers over the past two years since, it seems, commencing methotrexate. I am on a smaller dose of 7.5 mg once a week, but they still occurred, sometimes two or three at a time and lasting up to two weeks at a time, making eating extremely painful. I sought advice from my dentist and rheumatology team, but to no avail apart from increasing my folic acid to daily except on the methotrexate day. I then read in a woman's magazine about Vitamin B12 being a potential solution. I have been taking 25 mcg daily for the last six months and it has worked wonders. When I stopped it for a month out of curiosity, the ulcers came back, so needless to say, I will not be stopping them again. There are different dosages available, but I have found this small dose successful.
Wendy, London (Autumn 2009)

All hints and tips are provided by readers of our Arthritis Today magazine and aren’t necessarily the views of Arthritis Research UK.

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Links to sites and resources provided by third parties are provided for your general information only. We have no control over the contents of those sites or resources and we give no warranty about their accuracy or suitability. You should always consult with your GP or other medical professional.


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