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Tips on Flexiseq

FLEXISEQ hasn't worked for me

I suffer with arthritis in both my knees and was interested in the article in Arthritis Today Spring 2014 concerning FLEXISEQ. Reading of the success Sue Sharp had with the preparation, I purchased some to see what it might do for me. I have to admit it didn't seem to do anything like described in the article.

I noticed what was said about the preparation being a ‘medical device,’ but it doesn't contain any pharmaceutically active ingredients. What does it do, and what does it carry, if it's drug-free?

It was good that the user was relieved of her pain for a time, but I was disappointed that I felt no apparent effect from using it.
J.L. Ireland, via email (Summer 2014)

FLEXISEQ has worked for me

A friend purchased FLEXISEQ for me when she was in Germany. It made a big difference to my chronic pain in my knee, so much so I've decided to use it for my hip pain. Just a thought for your research.

I'm hoping NICE will approve it soon as my next lot will come from Ireland.
Doris, via email (Summer 2014)

Side-effects of FLEXISEQ

I tried using FLEXISEQ and found it helpful initially. However after about three weeks I did get the adverse skin reaction mentioned in the side-effects leaflet with signs of eczema so stopped using it. My skin is still not quite right even though I haven't used the gel for 10 days.

I may resume at a lower rate of application when it is fully healed. The skin had scaled so it looked like the mud at the bottom of a pond which has dried up!

I'm 77 years old so my skin will be thinning anyway. My friend who is 84 had a similar experience. Perhaps a lower dose should be recommended to older sufferers.
Enid, Slough, Berkshire (Summer 2014)

Note: FLEXISEQ gel contains compounds which pass through the skin and, according to research conducted by manufacturers Pro Bono Bio, reach the joint, creating a lubricating layer which protects cartilage.

Pro Bono Bio say that the product uses nano technology, as the topical gel is filled with nano-sized spheres called Sequessome vesicles, which contain compounds similar to those in the lubricating synovial fluid in joints.

Clinical trials have shown that the majority of patients using FLEXISEQ could expect to see a good clinical effect but it doesn't work for everyone and some people do experience skin reactions.

Arthritis Research UK isn't endorsing this product. FLEXISEQ is one of a range of options available to treat the joint pain associated with osteoarthritis. For further information on the product please visit

All hints and tips are provided by readers of our Arthritis Today magazine and aren’t necessarily the views of Arthritis Research UK.

Please send your hints to or sign up to Arthritis Today.

Links to sites and resources provided by third parties are provided for your general information only. We have no control over the contents of those sites or resources and we give no warranty about their accuracy or suitability. You should always consult with your GP or other medical professional.


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