Your feedback is very important to us.

How would you rate the quality of the information you have read today?

Did you find what you were looking for today?



We’re happy you found what you were looking for today – would you like to try one of our other services?

Virtual Assistant

Our new Arthritis Virtual Assistant uses artificial intelligence to answer your arthritis related questions 24/7.

Ask a question

Helpline

0800 5200 520

Open Mon–Fri 9am–8pm.

All calls are recorded for training and quality purposes.

Close

We are using cookies to give you the best experience on our site. Cookies are files stored in your browser and are used by most websites to help personalise your web experience.

By continuing to use our website without changing the settings, you are agreeing to our use of cookies.

Find out more

What can it do?

Welcome to the beta Arthritis Virtual Assistant. At the moment it can give you general information about your condition and medication, and provide you with useful exercises to help manage your arthritis.

Why do we need your help?

The Arthritis Virtual Assistant has been built to learn and improve with every use. That way, whenever you use it, you’re indirectly helping another person get the answers that they need for their arthritis.

What can you ask?

You'll get the best response if your question relates to a single type of arthritis, and is expressed as clearly and simply as possible. For example, "What are the best exercises for osteoarthritis?" or "What are the side effects of methotrexate?"

Close

Are you sure you want to close your conversation?

Your conversation will not be visible the next time you visit the Arthritis Virtual Assistant. If you want to keep a copy of the advice you've been given, you can print it using the button at the top of the chat window.

How would you rate your experience so far?

Close

Arthritis Virtual Assistant

The Arthritis Virtual Assistant (AVA) allows you to ask questions and get answers about your condition and how best to manage it. It’s based on over 80 years of our research and uses artificial intelligence to decide on the best responses to give you. The AVA is currently in ‘beta’ testing which means it’s still learning and will improve as more people use it.

The AVA provides general information. For further info, or if you have any concerns you should speak to a healthcare professional.

The AVA is intended for UK users. Medical practice may differ in different regions, so please seek local advice instead of using the AVA if you are outside the UK.

By using the AVA you confirm that you understand and accept the terms of use and consent to how we will use the information you provide.

See full terms
Helpline 0800 5200 520 More information

Call us for free information, help and advice on your type of arthritis.

All calls are recorded for training and quality purposes.
You are here:
> > > > How do I take methotrexate and how long does it take to work?

How do I take methotrexate and how long does it take to work?

Methotrexate is usually taken in tablet form once a week on the same day. The tablets should be swallowed whole and not crushed or chewed.

Methotrexate tablets come in two strengths, 2.5 mg and 10 mg. To avoid confusion it’s recommended that only the 2.5 mg tablet is used. The two strengths are different sizes but are a very similar colour, so you should always check the dose is correct.

In the early stages of a condition it’s often treated more aggressively and so the starting dose can range from 7.5–15 mg per week. Your doctor may then increase this dose if it isn’t helping your symptoms, but it won’t usually go higher than 25 mg weekly.

Alternatively, methotrexate may be given once a week by injection, usually subcutaneous, if there are side-effects with tablets. A subcutaneous injection is given into a layer of fat between the skin and muscle, rather than intravenously which means directly into a vein.

How long does it take to work?

Methotrexate is a long-term treatment, so it may be 3–12 weeks before you start to notice the benefits. Unless you have severe side-effects (in which case please see a health professional) it’s important to keep taking methotrexate:

  • even if it doesn’t seem to be working at first
  • even when your symptoms improve (as it will help to keep the disease under control).

Helpline

0800 5200 520

Our new helpline: Call us for free information, help and advice on your type of arthritis. Open Mon–Fri 9am–8pm.

All calls are recorded for training and quality purposes

Virtual Assistant

Our new Arthritis Virtual Assistant uses artificial intelligence to answer your arthritis related questions 24/7.

Ask a question
Close
For more information, go to www.arthritisresearchuk.org.
Arthritis Research UK fund research into the cause, treatment and cure of arthritis. You can support Arthritis Research UK by volunteering, donating or visiting our shops.