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What are the possible complications of Paget's disease?

Paget’s disease can lead to a number of other symptoms or complications that are potentially more serious:

Bone expansion – Affected bone expands and may become deformed due to the unusual cell activity. Long bones can curve so that one of your legs may end up shorter than the other.

Fractures – Although bone affected by Paget’s disease expands, it’s weaker than usual and is more likely to break than normal, healthy bone. Occasionally it may take longer for your bone to heal.

Nerve compression – When your bones expand they can sometimes squeeze nearby nerves. This most commonly happens in your spine, which can lead to weakness and tingling in your legs.

Deafness – If bones in your head have been affected it can result in a loss of hearing or deafness. This seems to be caused by thickening of the bones around your ear.

Osteoarthritis – If the condition reaches the end of your bone it can lead to osteoarthritis in your joint, causing pain and stiffness when it’s moved.

Tumours – Very rarely, a cancerous tumour can develop in a bone affected by Paget’s disease. It's estimated that this happens in less than 1 in 500 cases. The first signs of this are increased pain and swelling at the site of the tumour.


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