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  • Henderson CJ, Panush RS. Diets, dietary supplements and nutritional therapies in rheumatic diseases. Rheumatic Disease Clinics of North America 1999; 25(4):937–68.
  • Moskowitz, RW. Role of collagen hydrolysate in bone and joint disease. Seminars in Arthritis & Rheumatism 2000; 30(2):87–99.
  • Adam M. Therapie der osteoarthrose welche wirkung haben gelatineparaprate? Therapiewoche 1991;41:2456–61 [Article in German].
  • Cazzola M, Antivalle M, Sarzi-Puttini P, Dell’Acqua D, Panni B, Caruso. Oral type II collagen in the treatment of rheumatoid arthritis. A 6-month double-blind placebo controlled study. Clinical and Experimental Rheumatology 2000; 18(5):57–77.
  • McKown KM, Carbone LD, Kaplan SB, Aelion JA, Lohr KM, Cremer MA et al. Lack of efficacy of oral bovine type II collagen added to existing therapy in rheumatoid arthritis. Arthritis & Rheumatology 1999; 42(6):1204–08.
  • Wei W, Zhang L, Xu J et al. A multi-center double-blind, randomised, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis. Arthritis Research and Therapy 2009; 11:R180.
  • Crowley DC, Lau FC, Sharma P, Evans M, Guthrie M, Bagchi M, Bagchi D, Dey DK, Raychaudhuri SP. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. International Journal of Medical Sciences 2009; 6(6):312–21.
  • Benito-Ruiz P, Camacho-Zambrano MM, Carrillo-Arcentales JN, Mestanza-Peralta MA, Vallejo-Flores CA, Vargas-López SV, Villacís-Tamayo RA, Zurita-Gavilanes LA. A randomised controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International Journal of Food Sciences and Nutrition 2009; 60 (S2):99–113.
  • McAlindon TE, Nuite M, Krishnan N, Ruthazer R, Price LL, Burstein D, Griffith J, Flechsenhar K. Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomised controlled trial. Osteoarthritis and Cartilage 2011; 19:399–405.


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