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Vitamin B complex trials for osteoarthritis

Trial 1

In the first trial, 72 people with osteoarthritis were randomly selected to receive either 3 g vitamin B3 or placebo tablets once a day for 12 weeks.

  • Overall symptoms improved by 29% in participants given the vitamin and worsened by 10% in participants on the placebo, although neither group reported a reduction in pain.
  • In particular, vitamin B3 seemed to be effective in improving joint mobility compared to the placebo.
  • No major side-effects were reported, but the number of side-effects was higher in the vitamin B3 group.

Trial 2

In the second RCT, 29 people with hand osteoarthritis were randomised to receive either 6,400 μg vitamin B9, a combination of 6,400 μg vitamin B9 and 20 μg vitamin B12 or placebo tablets once a day for two months. Participants who received vitamin B9 and B12 had significantly better hand grip values compared to the other two treatment groups.


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