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Duhuo Jisheng Wan trials for osteoarthritis

In this trial, 200 participants with osteoarthritis of the knee were randomly given daily doses of one of the following:

  • 75 mg diclofenac tablets
  • 9 g Duhuo Jisheng Wan tablets
  • placebo tablets identical to the diclofenac
  • placebo tablets identical to the Duhuo Jisheng Wan.

The groups were compared with respect to side-effects and effectiveness over a four-week period.

  • Compared to the corresponding placebo groups, participants who received either Duhuo Jisheng Wan or diclofenac had significantly lower scores for pain and stiffness.
  • Compared to diclofenac, the beneficial effects of Duhuo Jisheng Wan were slower to develop.
  • Around 30% of participants in both groups receiving diclofenac and Duhuo Jisheng Wan reported side-effects; however, both groups also reported significantly more side-effects than the placebo groups.


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