Collagen trials for rheumatoid arthritis
Four trials tested collagen against a placebo and one tested it against methotrexate. The trials for involved between 60 and 503 participants with rheumatoid arthritis.
- Type II collagen showed fewer swollen joints, joint tenderness and better walk time in only one of the trials against a placebo.
- Although people in both groups improved in the type II collagen and methotrexate trial, the methotrexate participants showed the greatest improvement.
- There was no evidence of increased side-effects in people taking type II collagen, although trials did report participants withdrawing because they believed the collagen wasn’t improving their symptoms.