We are using cookies to give you the best experience on our site. Cookies are files stored in your browser and are used by most websites to help personalise your web experience.

By continuing to use our website without changing the settings, you are agreeing to our use of cookies.

Find out more

CFA trials for osteoarthritis

Two RCTs evaluated the role of CFAs in treating osteoarthritis of the knee. In both trials, the medication was well tolerated with no serious side-effects.

Trial 1‡

In the first trial, 64 participants were randomly assigned to receive either active capsules (350 mg of CFAs) or placebo capsules six times a day for 68 days. Participants were asked to continue taking their regular medication during the trial.

  • Neither group reported improvement in knee extension.
  • Participants in the active treatment group had significantly increased knee flexion.

Trial 2‡

Participants in the second trial were randomly selected to receive either CFA cream or a placebo cream. All 40 participants were asked to apply the cream to their knee twice a day for 30 days.

  • Those in the active treatment group experienced significant improvement in climbing stairs and standing up from a sitting position.
  • The overall range of motion of the knee was markedly improved in participants who used CFA cream.

‡ A trial of low quality. Results of this trial were given a lower weighting when we came to our conclusion about the compound.


0800 5200 520

Our new helpline: Call us for free information, help and advice on your type of arthritis. Open Mon–Fri 9am–8pm.

All calls are recorded for training and quality purposes

Virtual Assistant

Our new Arthritis Virtual Assistant uses artificial intelligence to answer your arthritis related questions 24/7.

Ask a question
For more information, go to
Arthritis Research UK fund research into the cause, treatment and cure of arthritis. You can support Arthritis Research UK by volunteering, donating or visiting our shops.