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Arthritis impacts all our lives

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CFA trials for osteoarthritis

Two RCTs evaluated the role of CFAs in treating osteoarthritis of the knee. In both trials, the medication was well tolerated with no serious side-effects.

Trial 1‡

In the first trial, 64 participants were randomly assigned to receive either active capsules (350 mg of CFAs) or placebo capsules six times a day for 68 days. Participants were asked to continue taking their regular medication during the trial.

  • Neither group reported improvement in knee extension.
  • Participants in the active treatment group had significantly increased knee flexion.

Trial 2‡

Participants in the second trial were randomly selected to receive either CFA cream or a placebo cream. All 40 participants were asked to apply the cream to their knee twice a day for 30 days.

  • Those in the active treatment group experienced significant improvement in climbing stairs and standing up from a sitting position.
  • The overall range of motion of the knee was markedly improved in participants who used CFA cream.

‡ A trial of low quality. Results of this trial were given a lower weighting when we came to our conclusion about the compound.

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