Close

We are using cookies to give you the best experience on our site. Cookies are files stored in your browser and are used by most websites to help personalise your web experience.

By continuing to use our website without changing the settings, you are agreeing to our use of cookies.

Find out more
For more information, go to www.arthritisresearchuk.org

Ibuprofen and intestinal injury

Issue 38 Synovium (Spring 2013)

Download this issue (opens in new window)(70.5 KB)

A paper in Medicine and Science in Sports and Exercise1 has demonstrated more potential hazards of NSAIDs to the gut. The authors had previously demonstrated that exercising to exhaustion for an hour causes temporary small intestinal injury and loss of gut barrier function (by measurements of plasma intestinal fatty acid binding protein and urinary excretion of ingested sugars respectively). In the current study 9 trained and healthy men were assessed for gastrointestinal injury and small intestinal permeability on 4 occasions: after (1) cycling having taken ibuprofen, (2) cycling without ibuprofen intake, (3) a period of rest having taken ibuprofen, and (4) rest without ibuprofen intake. The results demonstrated that taking ibuprofen increased the previously demonstrated temporary small-intestinal injury and gut permeability induced by exhaustive exercise. It is well known that many sports persons regularly take NSAIDs with the notion that this may reduce the experience of musculoskeletal pain during and after training and competition. This study suggests that this practice should be discouraged.

Synovium archives

Browse previous issues of Synovium (all issues available as downloadable PDFs)
For more information, go to www.arthritisresearchuk.org.
Arthritis Research UK fund research into the cause, treatment and cure of arthritis. You can support Arthritis Research UK by volunteering, donating or visiting our shops.