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Issue 25 Synovium (Autumn 2008)
Glucosamine has been a ‘frequent flyer’ in Synovium columns. To date evidence on chrondroitin sulphate (CS) – a related sulphated glycosaminoglycan – has lagged behind. A lengthy review of the biochemical properties of chondroitin sulphate in osteoarthritic articular tissues published in Annals of the Rheumatic Diseases1 may herald a change. The review details many effects of CS of potential benefit in osteoarthritis, including increasing synthesis of proteoglycans, inhibiting proteases, inhibiting changes in subchondral bone and inhibiting inflammatory processes. We await reports from clinical trials.
1. Monfort J, Pelletier JP, Garcia-Giralt N, Martel-Pelletier J. Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues. Ann Rheum Dis 2008 Jun;67(6):735-40.