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For more information, go to www.arthritisresearchuk.org

Why don't you have any information on Targinact?

Q) I searched your site for tramadol and saw a quote about there being a big gap in the market since co-proxamol was withdrawn, and that between paracetamol and tramadol there was a need for a stronger painkiller without the constipating side-effects of codeine (in co-codamol) and dihydrocodeine (in co-dydramol). I then searched your site for Targinact (which was featured in the Daily Mail recently) and it returned no result...this I find quite unbelievable and suggest that you immediately rectify. I'm a chronic pain sufferer among the millions abandoned by the medical profession.
Graham Thorpe, Hemel Hempstead, Hertfordshire (Spring 2011)

A) I agree that the withdrawal of co-proxamol has been a big blow to many patients. Funnily enough, small supplies of this drug are still available, if you know where to look for it and if your GP will prescribe it. And I completely agree that the constipating effect of morphine-like drugs is a big drawback. However, I'm not sure that Targinact is the perfect solution. The Drug and Therapeutics Bulletin, a respected independent publication, had this to say about it: 'The studies have provided few data to show that Targinact reduces, let alone eliminates, the need for laxatives in the long term, or whether it offers advantages for people with cancer. There are no published studies comparing Targinact with other oral strong opioids given with regular stool-softening and stimulant laxatives. Targinact is more expensive than oral morphine plus regular laxatives.'

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