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Does tocilizumab affect fertility, pregnancy or breastfeeding?

We don’t yet know how tocilizumab might affect an unborn baby, so generally women of childbearing age are advised to use contraception during treatment and for three months afterwards. You should speak to your doctor if you become pregnant while taking it.

However, we do know tocilizumab doesn't cross the placenta until 16 weeks of pregnancy so it's unlikely to be harmful if you've taken it in the early stages of pregnancy.

If you're also taking methotrexate you should use contraception for three months after stopping treatment. The guidelines now state that there's no need for men to stop methotrexate when trying to father a child.

We don’t know whether tocilizumab can pass into the breast milk and be harmful to your baby. The current advice is not to breastfeed while you're on tocilizumab.


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