Methotrexate is a disease-modifying anti-rheumatic drug (DMARD). It reduces the activity of the body’s defence system (immune system).
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It’s used to treat auto-immune conditions such as rheumatoid arthritis, psoriatic arthritis and vasculitis.
It’s usually given as weekly 2.5 mg tablets or injection.
In some patients methotrexate can cause nausea (feeling sick), vomiting, diarrhoea, mouth ulcers, hair loss and skin rashes. It can also make you more likely to develop infections.