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What is a wash-out treatment and why might I need it?

Leflunomide can remain in the body for up to a year after you stop taking it.

In some circumstances it's recommended that leflunomide is eliminated from the body more quickly for example if:

  • you become pregnant
  • you have severe side-effects from leflunomide
  • you need to start another treatment that could interact with leflunomide.

A wash-out treatment will help to remove leflunomide from your body more quickly than usual. This involves taking a drug called cholestyramine for 11 days. You may have blood tests to check that the level of leflunomide in your body is falling.

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