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What is denosumab and why is it prescribed?

Denosumab works by blocking a protein called RANK ligand, which occurs naturally in the body. Blocking this protein limits the activity of cells (osteoclasts) that break down old bone material. It therefore helps to increase bone mass and strength.

Denosumab is recommended for osteoporosis in:

  • postmenopausal women who can't take bisphosphonates
  • men who have developed osteoporosis as a result of treatment for prostate cancer.


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