Amitriptyline used to treat chronic (long-term) pain caused by arthritis, neck and spine problems, fibromyalgia, chronic headaches and peripheral neuropathy (damage to nerve endings in the upper and lower limbs).
Amitriptyline shouldn’t be used if you've recently had a heart attack. It also shouldn’t be used if you have uncontrolled bipolar disorder, acute porphyria or heart block.
Amitriptyline is usually taken as tablets or syrup once a day, about two hours before bedtime. The usual dose for chronic pain is 5–50 mg daily, though higher doses may be prescribed.
It may take several weeks before it starts to work.
You can have vaccinations while on amitriptyline but you should avoid drinking alcohol. Amitriptyline isn’t
generally recommended during pregnancy or while breastfeeding but you shouldn’t stop
taking it suddenly or without talking to your doctor.
You won't need any special checks while you’re on amitriptyline, but you should discuss any new medications (including complementary medicines) with your doctor before starting them and always tell any other doctor treating you that you’re taking amitriptyline because some drugs interact with amitriptyline.
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