We are using cookies to give you the best experience on our site. Cookies are files stored in your browser and are used by most websites to help personalise your web experience.

By continuing to use our website without changing the settings, you are agreeing to our use of cookies.

Find out more
You are here:
> > > > Can allopurinol affect other medicines and treatments?

Can allopurinol affect other medicines and treatments?

You'll probably need a non-steroidal anti-inflammatory drug (NSAID), colchicine or steroids to deal with attacks of gout – especially in the early stages of allopurinol treatment. However, some drugs may interact with allopurinol, so you should discuss any new medication with your doctor before starting it, and you should always tell anyone else treating you that you're taking allopurinol.

  • Allopurinol interacts with the immunosuppressant drugs azathioprine and mercaptopurine and these drugs should not generally be used with allopurinol.
  • Allopurinol may increase the risk of developing a rash with the antibiotics ampicillin and amoxicillin.
  • Allopurinol may increase the effect of warfarin and other drugs that thin the blood (anticoagulants), so you may need to have your blood clotting tested more frequently.

Can I have vaccinations while I'm on allopurinol?

You can have vaccinations while on allopurinol.


0800 5200 520

Our new helpline: Call us for free information, help and advice on your type of arthritis.

All calls are recorded for training and quality purposes

More Information Close
For more information, go to
Arthritis Research UK fund research into the cause, treatment and cure of arthritis. You can support Arthritis Research UK by volunteering, donating or visiting our shops.