What causes Paget's disease?
We don’t yet know exactly what causes Paget’s disease but the following factors may play a part:
Genetic factors – About 10–15 in every 100 people with Paget’s disease have relatives who also have the condition. In these cases the condition can be passed on from one generation to the next. But often there’s no family history of the condition.
Lifestyle factors – There's some evidence that poor diet or a bone injury early in life may act as triggers for the later development of Paget’s in people who also have genetic risk factors.
Another theory is that Paget's disease may be linked to a viral infection early in life, but some experts dispute this.
Arthritis Research UK also recently awarded a grant for a study into what causes Paget's disease and how complications can be prevented.