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Paget's disease of bone

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What is Paget's disease of bone?

Paget’s disease of the bone affects the way that your bone is renewed and repaired. This process becomes quicker and chaotic, resulting in abnormally shaped bone with an unusual structure. The affected bone is weaker than normal, can become bent or deformed and may break more easily. Paget’s disease can also cause damage to the joints close to the affected bone. Read more >

What are the symptoms of Paget's disease?

You may have no symptoms at all, but if you do the most common symptom is pain in the following areas:
  • the affected bone
  • your joints near the affected bones
  • your back, neck and legs, caused by an enlarged bone pressing on a nerve

The bones most commonly affected are:

  • pelvis
  • spine
  • thigh
  • shin
  • skull
Read more >

What are the possible complications of Paget's disease?

In time, Paget’s disease can lead to a number of complications:
  • bone deformity (bending)
  • bone enlargement
  • fractures
  • compression of nerves
  • deafness
  • osteoarthritis
  • tumours (this is very rare)
Read more >

Who gets Paget's disease?

Paget’s disease is most common in the UK but also occurs in people from western and southern Europe, as well as Australia and New Zealand (where many Europeans have emigrated in the past). About 2–3 people in 100 over the age of 50 have Paget’s disease in some part of their skeleton. Read more >

What causes Paget's disease?

We don’t yet know exactly what causes Paget’s disease but it may be any of the following:
  • genetic factors
  • lifestyle factors
  • a viral infection early in life
Read more >

How is Paget's disease diagnosed?

A diagnosis of Paget's disease will be based on your symptoms and a physical examination, but you'll often need x-rays and blood tests to confirm it. Read more >

What treatments are there for Paget's disease?

You may be prescribed painkillers and a group of drugs called bisphosphonates, which can be given as infusions (injections directly into the blood stream) or as tablets. You may need surgery if you fracture a bone. If your symptoms are particularly bad your doctor may suggest you have joint replacement surgery. Read more >

Self-help and daily living for Paget's disease

Try the following tips to help ease the symptoms of Paget's disease: Read more >

Research and new developments for Paget's disease

Recent research has identified particular gene abnormalities that may contribute to the development of Paget’s disease. Read more >
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