Research and new developments for osteoarthritis of the knee

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Arthritis Research UK is funding many studies to find and test new treatments for osteoarthritis, including:

  • the VIDEO study, which is looking into the benefits of vitamin D
  • the arcOGEN study, which is investigating the genes involved in osteoarthritis
  • early trials of stem-cell research which aims to regrow cartilage.

Arthritis Research UK has also awarded a grant for the PROMOTE trial, a study into whether methotrexate, a drug commonly used to treat rheumatoid arthritis, can be used to treat osteoarthritis of the knee. Another grant will look into whether the drug spironolactone reduces pain in older people with osteoarthritis of the knee.

We've also recently opened the Arthritis Research UK Centre for Osteoarthritis Pathogenesis, which will look to understand why osteoarthritis develops, and begun to fund a study into a new approach to knee osteoarthritis. Preliminary work by this research group has identified four distinct subgroups of osteoarthritis. The aim of this research project is to verify these different subsets and identify ways the disease could be  identified and treated in these different groups of patients.

Noisy knees

Researchers funded by Arthritis Research UK have developed a prototype device that could help detect the onset of osteoarthritis in the knee by measuring the sounds it makes, which could help GPs to make a quicker diagnosis. It works by scanning your knees for sounds that suggests your knee joint is deteriorating. The device is still being developed and is undergoing extensive tests, so it’s not widely available yet.

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PROMOTE: A trial of methotrexate to treat painful knee osteoarthritis

A clinical study testing a drug for the treatment of pain in knee osteoarthritis