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Vitamins A, C and E trials for rheumatoid arthritis

Three of the four trials in this review article investigated the potential role of vitamin E in treating rheumatoid arthritis, while the fourth studied the effectiveness of selenium ACE treatment.

  • In the first trial‡ (42 people over a 12-week period), there was no significant difference between participants on 1,200 mg per day vitamin E supplements or a placebo in morning stiffness, number of swollen joints and degree of joint tenderness, but there was a significant difference in pain reduction in favour of participants taking vitamin E.
  • In both the second trial (41 people over a three-week period) and the third trial (85 people over a three-week period), there was no significant difference between participants allocated 1,200 mg a day vitamin E supplements or participants given 150 mg diclofenac (a non-steroidal anti-inflammatory drug) a day in all aspects of disease severity at the end of the trial.
  • In the fourth trial‡ (20 people over a six-month period), there was no significant difference between participants who received selenium ACE supplements or participants on a placebo in all aspects of disease severity at the end of the trial.

‡ A trial of low quality. Results of this trial were given a lower weighting when we came to our conclusion about the compound.

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