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Green-lipped mussel trials for osteoarthritis

Review article‡

The number of participants involved in the trials included in this review ranged from 30–80. The trials lasted between three and six months. Three of these trials (two of which were low quality) compared the potential beneficial effects of green-lipped mussel supplements with placebo capsules. The fourth trial, also of low quality, compared the effectiveness of two forms of the compound (the lipid extract versus powder).

Green-lipped mussel was more effective than a placebo in reducing pain, improving function and improving overall quality of life when taken along with usual painkillers (for example paracetamol) and NSAIDs.

Both forms were effective, with 73% of the lipid group and 87% of the powder group showing significant improvement.

‡ A trial of low quality. Results of this trial were given a lower weighting when we came to our conclusion about the compound.<

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