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Collagen trials for rheumatoid arthritis

Four trials tested collagen against a placebo and one tested it against methotrexate. The trials for involved between 60 and 503 participants with rheumatoid arthritis.

  • Type II collagen showed fewer swollen joints, joint tenderness and better walk time in only one of the trials against a placebo.
  • Although people in both groups improved in the type II collagen and methotrexate trial, the methotrexate participants showed the greatest improvement.
  • There was no evidence of increased side-effects in people taking type II collagen, although trials did report participants withdrawing because they believed the collagen wasn’t improving their symptoms.

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