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SAMe trials for fibromyalgia

Three out of four published RCTs found that SAMe was effective, when compared to a placebo, in reducing the number of tender points and/or the intensity of tenderness of these points in people with fibromyagia. The three studies also found that SAMe was effective, compared to placebo, in reducing depressive symptoms.

The fourth RCT found that SAMe wasn’t significantly better than a placebo in reducing almost all disease-related symptoms; however, the number of participants who took part in these four trials was small (17–44 participants) and length of treatment was short (10 days–6 weeks).

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