Anthocyanidins trials for fibromyalgia
A small trial of 12 participants evaluated the role of anthocyanidins in treating fibromyalgia. Participants were given one of the following once a day for three months:
- 40 mg of anthocyanidins
- 80 mg of anthocyanidins
- 120 mg of antocyanidins
- placebo tablets.
Participants were asked to report the severity of their pain, the degree of fatigue and sleep problems in a daily diary. The investigator also evaluated the improvement of these symptoms by interviewing the participants once every month.
- Anthocyanidins weren’t effective in reducing pain (as evaluated by the participant and the investigator) at any daily doses during any part of the follow-up.
- Participants reported a similar lack of effect on fatigue, although the investigators observed some beneficial effect during the interviews.
- A significant reduction in sleep disturbance was reported in the daily reports of participants taking anthocyanidins compared to those on the placebo, but such beneficial effects weren’t confirmed by the investigators during interviews.
- Participants who were on anthocyanidins reported more side-effects than those who were given placebo capsules.