Goal 5 - Understand how arthritis starts and develops.
Understand how arthritis starts and develops
We will have a detailed understanding of the causes and consequences of most forms of arthritis.
How we will measure this
We will review our understanding of the causes and development of the different forms of arthritis in consultation with experts. We will continue with our programme of targeted, expert workshops which review the progress made to achieve an understanding of the underlying risk factors and the pathological processes that cause the specific forms of arthritis.
Where we are now
We have a good understanding of the size of the genetic contribution to arthritis and of some of the specific genes involved. We need to know how these genes act to cause arthritis.
We have a good understanding of the role of host factors such as growth, body build and hormonal factors and how they might influence the development of arthritis.
We have a good understanding of the role of lifestyle exposures including patterns of work plus individual lifestyle choices such as diet and cigarette smoking and how they might influence the development of arthritis.
We need to know more about how all these factors interact, as it is combinations of factors that are likely to cause arthritis.
Research is helping us to understand how these triggers alter normal processes of musculoskeletal tissue repair and response to injury and infection which can lead to arthritis.
What we will be doing:
- Supporting a broad portfolio of world-class research in the UK directed at a greater understanding the predisposing factors that cause arthritis and their impact on normal biology
- Developing a research strategy that balances response mode and directed research in this area.